Honors Theses


Anne R. Crecelius


Health and Sport Science

Publication Date


Document Type

Honors Thesis


Impairments in neurological and physical functioning occur in conditions of decreased oxygen delivery to tissue cells. This study examined the effects of remote ischemic preconditioning (RIPC) and tested the hypothesis that RIPC can attenuate the hypoxia-induced decline in cognitive function and exercise performance. Twelve young, healthy men and women participated in two experimental sessions, where they completed two trial series of cognitive tests and graded handgrip exercises, once in normoxia, and once in hypoxia. The cognitive tests (CNS Vital Signs) measured composite memory, verbal memory, visual memory, and processing speed. During rest and exercise trials, forearm blood flow (FBF) and forearm vascular conductance (FVC) responses were measured (Doppler ultrasound). One experimental session included RIPC between trials whereas the other included a sham intervention. FBF and FVC was similar between sham and experimental conditions (p=0.685, p=0.767, respectively). Additionally, the RIPC intervention did not significantly impact changes in cognitive function during hypoxic trials. We conclude that the RIPC intervention did not have a significant impact on exercise hyperemia or cognitive function in hypoxic conditions.

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Undergraduate research

Embargoed until Sunday, June 23, 2120