Honors Theses

Advisor

Anne R. Crecelius

Department

Health and Sport Science

Publication Date

4-26-2020

Document Type

Honors Thesis

Abstract

Impairments in neurological and physical functioning occur in conditions of decreased oxygen delivery to tissue cells. This study examined the effects of remote ischemic preconditioning (RIPC) and tested the hypothesis that RIPC can attenuate the hypoxia-induced decline in cognitive function and exercise performance. Twelve young, healthy men and women participated in two experimental sessions, where they completed two trial series of cognitive tests and graded handgrip exercises, once in normoxia, and once in hypoxia. The cognitive tests (CNS Vital Signs) measured composite memory, verbal memory, visual memory, and processing speed. During rest and exercise trials, forearm blood flow (FBF) and forearm vascular conductance (FVC) responses were measured (Doppler ultrasound). One experimental session included RIPC between trials whereas the other included a sham intervention. FBF and FVC was similar between sham and experimental conditions (p=0.685, p=0.767, respectively). Additionally, the RIPC intervention did not significantly impact changes in cognitive function during hypoxic trials. We conclude that the RIPC intervention did not have a significant impact on exercise hyperemia or cognitive function in hypoxic conditions.

Permission Statement

This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes.

Embargoed until Sunday, June 23, 2120


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