Gliomas, which are brain tumors that arise from glial cells, are some of the most aggressive and lethal types of tumors. These brain tumors are difficult to treat because not enough information regarding the mutations present in these tumors exists. This project studies effects of a p53 mutation on Drosophila glioma progression and then will test to see if this results in resistance to current chemotherapy. The main goal of this endeavor is to investigate the numerous defects occurring at the cellular and biochemical level in gliomas, which will give insight into why these types of tumors are so difficult to treat. Additionally, this document also discusses some promising chemotherapeutic agents found through a drug screen project. The effects of five different Tyrosine Kinase inhibitors on glioma development are presented here.
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Alleman, Kaitlyn M., "Investigating the Effects of a p53 Mutation and Various Tyrosine Kinase Inhibitors on Glioma Progression and Therapy Resistance in Drosophila" (2021). Honors Theses. 304.