Document Type

Article

Publication Date

2012

Publication Source

Human Genomics

Abstract

In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.

ISBN/ISSN

1473-9542

Document Version

Published Version

Publisher

BioMed Central

Volume

6

Issue

10

Keywords

Biomed Central Ltd, Review, X-Ray Analysis, Histone Fold, Crystal-Structure, Dna-Binding, Angstrom Resolution, Fourier Synthesis, Zinc Fingers, Complex Reveals, Oxygen-Affinity, Helix Domain

Link to published version

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