"Conservation of the Three-Dimensional Structure in Non-Homologous Or U" by Konstantinos Sousounis, Carl E. Haney et al.
 

Document Type

Article

Publication Date

2012

Publication Source

Human Genomics

Abstract

In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.

ISBN/ISSN

1473-9542

Document Version

Published Version

Publisher

BioMed Central

Volume

6

Issue

10

Keywords

Biomed Central Ltd, Review, X-Ray Analysis, Histone Fold, Crystal-Structure, Dna-Binding, Angstrom Resolution, Fourier Synthesis, Zinc Fingers, Complex Reveals, Oxygen-Affinity, Helix Domain

Link to published version

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