Document Type
Article
Publication Date
11-2013
Publication Source
Advances in Nanoparticles
Abstract
Investigations into the use of gold nanorods (Au-NRs) for biological applications are growing exponentially due to their distinctive physicochemical properties, which make them advantageous over other nanomaterials. Au-NRs are particularly renowned for their plasmonic characteristics, which generate a robust photothermal response when stimulated with light at a wavelength matching their surface plasmon resonance. Numerous reports have explored this nanophotonic phenomenon for temperature driven therapies; however, to date there is a significant knowledge gap pertaining to the kinetic heating profile of Au-NRs within a controlled physiological setting. In the present study, the impact of environmental composition on Au-NR behavior and degree of laser actuated thermal production was assessed. Through acellular evaluation, we identified a loss of photothermal efficiency in biologically relevant fluids and linked this response to excessive particle aggregation and an altered Au-NR spectral profile. Furthermore, to evaluate the potential impact of solution composition on the efficacy of nano-based biological applications, the degree of targeted cellular destruction was ascertained in vitro and was found to be susceptible to fluid-dependent modifications. In summary, this study identified a diminution of Au-NR nanophotonic response in artificial physiological fluids that translated to a loss of application efficiency, pinpointing a critical concern that must be considered to advance in vivo, nano-based bio-applications.
Inclusive pages
336-343
ISBN/ISSN
2169-0510
Document Version
Published Version
Copyright
Copyright © 2013 Kristen K. Comfort et al.
Publisher
Scientific Research Publishing
Volume
2
Peer Reviewed
yes
Issue
4
eCommons Citation
Comfort, Kristen K.; Speltz, Jared W.; Stacy, Bradley M.; Dosser, Larry R.; and Hussain, Saber M., "Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics" (2013). Chemical and Materials Engineering Faculty Publications. 5.
https://ecommons.udayton.edu/cme_fac_pub/5
Included in
Biomechanics and Biotransport Commons, Other Biomedical Engineering and Bioengineering Commons, Other Chemical Engineering Commons, Other Materials Science and Engineering Commons, Polymer and Organic Materials Commons
Comments
This is an open-access article distributed under the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Permission documentation is on file.