Title
Facile Preparation of N-methyl Secondary Amines by Titanium(IV) Isopropoxide-Mediated Reductive Amination of Carbonyl Compounds
Document Type
Article
Publication Date
1998
Publication Source
Journal of the Chemical Society
Abstract
A simple, mild and efficient procedure for obtaining N-methyl secondary amines from aldehydes and ketones is reported. Treatment of carbonyl compounds with methylamine hydrochloride, triethylamine and titanium(IV) isopropoxide, followed by in situ sodium borohydride reduction and straightforward aqueous work-up, affords clean products in good to excellent yields.
Inclusive pages
2527-2532
ISBN/ISSN
0368-1769
Copyright
Copyright © 1998, Royal Society of Chemistry
Publisher
Royal Society of Chemistry
Issue
16
Peer Reviewed
yes
eCommons Citation
Neidigh, Kurt A.; Avery, Mitchell A.; Williamson, John S.; and Bhattacharyya, Sukanta, "Facile Preparation of N-methyl Secondary Amines by Titanium(IV) Isopropoxide-Mediated Reductive Amination of Carbonyl Compounds" (1998). Office for Research Publications and Presentations. 21.
https://ecommons.udayton.edu/ofr_pub/21
COinS
Comments
Permission documentation is on file.