Facile Preparation of N-methyl Secondary Amines by Titanium(IV) Isopropoxide-Mediated Reductive Amination of Carbonyl Compounds

Author(s)

Kurt A. Neidigh, University of Mississippi
Mitchell A. Avery, University of Mississippi
John S. Williamson, University of DaytonFollow
Sukanta Bhattacharyya, Vijoygarh College

Document Type

Article

Publication Date

1998

Publication Source

Journal of the Chemical Society

Abstract

A simple, mild and efficient procedure for obtaining N-methyl secondary amines from aldehydes and ketones is reported. Treatment of carbonyl compounds with methylamine hydrochloride, triethylamine and titanium(IV) isopropoxide, followed by in situ sodium borohydride reduction and straightforward aqueous work-up, affords clean products in good to excellent yields.

Inclusive pages

2527-2532

ISBN/ISSN

0368-1769

Comments

Permission documentation is on file.

Copyright

Copyright © 1998, Royal Society of Chemistry

Publisher

Royal Society of Chemistry

Issue

16

Peer Reviewed

yes

eCommons Citation

Neidigh, Kurt A.; Avery, Mitchell A.; Williamson, John S.; and Bhattacharyya, Sukanta, "Facile Preparation of N-methyl Secondary Amines by Titanium(IV) Isopropoxide-Mediated Reductive Amination of Carbonyl Compounds" (1998). Office for Research Publications and Presentations. 21.
https://ecommons.udayton.edu/ofr_pub/21