Title

Facile Preparation of N-methyl Secondary Amines by Titanium(IV) Isopropoxide-Mediated Reductive Amination of Carbonyl Compounds

Document Type

Article

Publication Date

1998

Publication Source

Journal of the Chemical Society

Abstract

A simple, mild and efficient procedure for obtaining N-methyl secondary amines from aldehydes and ketones is reported. Treatment of carbonyl compounds with methylamine hydrochloride, triethylamine and titanium(IV) isopropoxide, followed by in situ sodium borohydride reduction and straightforward aqueous work-up, affords clean products in good to excellent yields.

Inclusive pages

2527-2532

ISBN/ISSN

0368-1769

Comments

Permission documentation is on file.

Publisher

Royal Society of Chemistry

Issue

16

Peer Reviewed

yes