Biotransformation of 10-deoxoartemisinin to its 7β-hydroxy Derivative by Mucor ramannianus

Author(s)

Sorele Fiaux de Medeiros, Universidade Federal do Rio de Janeiro
Mitchell A. Avery, University of Mississippi
Bonnie A. Avery, University of Mississippi
Selma G.F. Leite, Universidade Federal do Rio de Janeiro
Antonio Carlos C. Freitas, Universidade Federal Fluminense
John S. Williamson, University of DaytonFollow

Document Type

Article

Publication Date

6-2002

Publication Source

Biotechnology Letters

Abstract

10-Deoxoartemisinin at 0.2 mg ml^₋₁ medium was transformed to 7β-hydroxy deoxoartemisinin by Mucor ramannianus growing on sucrose, 20 g l⁻¹, and peptone, 10 g l⁻¹, at pH 4 and 26 °C. The yield of product was increased from 16% to 45% by selecting optimal culture conditions using a 2⁵⁻² factorial design.

Inclusive pages

937–941

ISBN/ISSN

0141-5492

Comments

Permission documentation is on file.

Copyright

Copyright © 2002, Kluwer Academic Publishers

Publisher

Springer

Volume

24

Issue

11

Peer Reviewed

yes

eCommons Citation

Fiaux de Medeiros, Sorele; Avery, Mitchell A.; Avery, Bonnie A.; Leite, Selma G.F.; Freitas, Antonio Carlos C.; and Williamson, John S., "Biotransformation of 10-deoxoartemisinin to its 7β-hydroxy Derivative by Mucor ramannianus" (2002). Office for Research Publications and Presentations. 25.
https://ecommons.udayton.edu/ofr_pub/25