Novel Peptide Mimetic Inhibitors of Hepatitis C Serine Protease Derived from Isomannide

Author(s)

Thalita G. Barros, Universidade Federal Fluminense
Sergio Pinheiro, Universidade Federal Fluminense
John S. Williamson, University of DaytonFollow
Amilcar Tanuri, Federal University of Rio de Janeiro
Helena S. Pereira, Federal University of Rio de Janeiro
Rodrigo M. Brindeiro, Federal University of Rio de Janeiro
José B. A. Neto, Federal University of Rio de Janeiro
Octavio A.C. Antunes, Universidade do Brasil
Estela M.F. Muri, Universidade do Brasil

Document Type

Article

Publication Date

2009

Publication Source

Synthesis

Abstract

Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the most studied class of proteolytic enzymes­, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel­ class of peptide mimetic compounds as potential HCV serine protease inhibitors.

Inclusive pages

620-626

ISBN/ISSN

0039-7881

Comments

Permission documentation is on file.

Copyright

Copyright © 2009, Georg Thieme Verlag Stuttgart

Publisher

Georg Thieme Verlag Stuttgart

Volume

4

Peer Reviewed

yes

eCommons Citation

Barros, Thalita G.; Pinheiro, Sergio; Williamson, John S.; Tanuri, Amilcar; Pereira, Helena S.; Brindeiro, Rodrigo M.; Neto, José B. A.; Antunes, Octavio A.C.; and Muri, Estela M.F., "Novel Peptide Mimetic Inhibitors of Hepatitis C Serine Protease Derived from Isomannide" (2009). Office for Research Publications and Presentations. 36.
https://ecommons.udayton.edu/ofr_pub/36