Hydroxamic Acids Designed as Inhibitors of Urease

Author(s)

Thalita G. Barros, Universidade Federal Fluminense
John S. Williamson, University of DaytonFollow
Octavio A.C. Antunes, Universidade do Brasil
Estela M.F. Muri, Universidade do Brasil

Document Type

Article

Publication Date

2009

Publication Source

Letters in Drug Design & Discovery

Abstract

Urease is an enzyme responsible for the hydrolysis of urea into ammonia and carbamate. Humans infected by urease are exposed to a risk of chronic gastritis or cancer. Urease inhibitors have attracted a great deal of attention for their potential as new anti-ulcer drugs. Here, we describe the synthesis of series of hydroxamic acid compounds designed as inhibitors of urease.

Inclusive pages

186-192

ISBN/ISSN

1570-1808

Comments

Permission documentation is on file.

Copyright

Copyright © 2009, Bentham Science Publishers

Publisher

Bentham Science Publishers

Volume

6

Issue

3

Peer Reviewed

yes

eCommons Citation

Barros, Thalita G.; Williamson, John S.; Antunes, Octavio A.C.; and Muri, Estela M.F., "Hydroxamic Acids Designed as Inhibitors of Urease" (2009). Office for Research Publications and Presentations. 37.
https://ecommons.udayton.edu/ofr_pub/37