Title

Hydroxamic Acids Designed as Inhibitors of Urease

Document Type

Article

Publication Date

2009

Publication Source

Letters in Drug Design & Discovery

Abstract

Urease is an enzyme responsible for the hydrolysis of urea into ammonia and carbamate. Humans infected by urease are exposed to a risk of chronic gastritis or cancer. Urease inhibitors have attracted a great deal of attention for their potential as new anti-ulcer drugs. Here, we describe the synthesis of series of hydroxamic acid compounds designed as inhibitors of urease.

Inclusive pages

186-192

ISBN/ISSN

1570-1808

Comments

Permission documentation is on file.

Publisher

Bentham Science Publishers

Volume

6

Issue

3

Peer Reviewed

yes