"Excretion and Conservation of Glycerol, and Expression of Aquaporins a" by Sarah L. Zimmerman, James Frisbie et al.
 

Excretion and Conservation of Glycerol, and Expression of Aquaporins and Glyceroporins, During Cold Acclimation in Cope's Gray Tree Frog Hyla Chrysoscelis

Document Type

Article

Publication Date

1-2007

Publication Source

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Abstract

Cope's gray tree frog Hyla chrysoscelis accumulates glycerol during cold acclimation. We hypothesized that, during this process, gray tree frogs adjust renal filtration and/or reabsorption rates to retain accumulated glycerol. During cold acclimation, plasma concentrations of glycerol rose >200-fold, to 51 mmol/l. Although fractional water reabsorption decreased, glomerular filtration rate (GFR) and, consequently, urine flow wereXenopus oocyte expression system. HC-1, an AQP1-like water channel conferring low glycerol permeability, is expressed ubiquitously in warm- and cold-acclimated tissues. HC-2, a water channel most similar to AQP2, is primarily expressed in organs of osmoregulation. HC-3, which is most similar to AQP3, is functionally characterized as a GLP, with low permeability to water but high permeability to glycerol. Aspects of expression levels and functional characteristics varied between cold and warm conditions for each of the three AQPs, suggesting a complex pattern of involvement in osmoregulation related to thermal acclimation.

Inclusive pages

R544-R555

ISBN/ISSN

0363-6119

Comments

Permission documentation is on file.

This research was supported in part by National Science Foundation Research Grant IOB-0517301 to D.L. Goldstein and C.M. Krane.

Publisher

American Physiological Society

Volume

292

Peer Reviewed

yes

Issue

1

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