Document Type
Article
Publication Date
3-2019
Publication Source
Diagnostic Microbiology and Infectious Disease
Abstract
The mechanism of resistance in carbapenem-resistant Enterobacteriaceae (CRE) has therapeutic implications. We comprehensively characterized emerging mechanisms of resistance in CRE between 2013 and 2016 at a health system in Northern California. A total of 38.7% (24/62) of CRE isolates were carbapenemase gene-positive, comprising 25.0% (6/24) blaOXA-48 like, 20.8% (5/24) blaKPC, 20.8% (5/24) blaNDM, 20.8% (5/24) blaSME, 8.3% (2/24) blaIMP, and 4.2% (1/24) blaVIM. Between carbapenemases and porin loss, the resistance mechanism was identified in 95.2% (59/62) of CRE isolates. Isolates expressing blaKPC were 100% susceptible to ceftazidime–avibactam, meropenem–vaborbactam, and imipenem–relebactam; blaOXA-48 like–positive isolates were 100% susceptible to ceftazidime–avibactam; and metallo β-lactamase–positive isolates were nearly all nonsusceptible to above antibiotics. Carbapenemase gene-negative CRE were 100% (38/38), 92.1% (35/38), 89.5% (34/38), and 31.6% (12/38) susceptible to ceftazidime–avibactam, meropenem–vaborbactam, imipenem–relebactam, and ceftolozane–tazobactam, respectively. None of the CRE strains were identical by whole genome sequencing. At this health system, CRE were mediated by diverse mechanisms with predictable susceptibility to newer β-lactamase inhibitors.
Inclusive pages
250-257
ISBN/ISSN
Print ISSN: 0732-8893; Online ISSN: 1879-0070
Document Version
Postprint
Copyright
Copyright © 2023 Elsevier Inc. All rights reserved
Publisher
Elsevier
Volume
93
Peer Reviewed
yes
Issue
3
Keywords
Carbapenem-resistant Enterobacteriaceae, Carbapenemase, Porin, Avibactam, Relebactam, Vaborbactam
eCommons Citation
Senchyna, Fiona; Gaur, Rajiv L.; Sandlund, Johanna; Truong, Cynthia; Tremintin, Guillaume; Kültz, Dietmar; Gomez, Carlos A.; Tamburini, Fiona B.; Andermann, Tessa; Bhatt, Ami; Tickler, Isabella A.; Watz, Nancy; Budvytiene, Indre; Shi, Gongyi; Tenover, Fred C.; and Banaei, Niaz, "Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016" (2019). Biology Faculty Publications. 331.
https://ecommons.udayton.edu/bio_fac_pub/331
Included in
Biology Commons, Biotechnology Commons, Cell Biology Commons, Genetics Commons, Microbiology Commons, Molecular Genetics Commons
Comments
The document available for download is the authors' accepted manuscript, provided in compliance with the publisher's policy on self-archiving. Permission documentation is on file. Version of record: https://doi.org/10.1016/j.diagmicrobio.2018.10.004
It is licensed under the Creative Commons CC-BY-NC-ND license.