Document Type
Article
Publication Date
2026
Publication Source
Journal of Antimicrobial Chemotherapy
Abstract
The global emergence and dissemination of epidemic Clostridioides difficile ribotype 027 (RT027) and related lineages illustrate the role of antimicrobial pressure in shaping the epidemiology of this pathogen. We propose a hierarchical model in which fluoroquinolones (FQs) served as the dominant selective force underlying the worldwide expansion of RT027-related strains, with rifampin and rifamycins acting as secondary modifiers that promoted persistence and regional dominance. ©
ISBN/ISSN
ISSN 0305-7453; eISSN 1460-2091
Document Version
Published Version
Copyright
Copyright © The Author(s) 2026.
Publisher
Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy
Volume
81
Peer Reviewed
yes
eCommons Citation
Tickler, Isabella A.; Goering, Richard V.; and Tenover, Fred, "The underappreciated role of rifampin in shaping the epidemiology of RT027-like Clostridioides difficile lineages" (2026). Biology Faculty Publications. 389.
https://ecommons.udayton.edu/bio_fac_pub/389
Comments
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: https://doi.org/10.1093/jac/dkag310