Document Type
Article
Publication Date
2013
Publication Source
ACS Applied Materials & Interfaces
Abstract
One of the primary challenges associated with nanoparticle-dependent biological applications is that endosomal entrapment in a physiological environment severely limits the desired targeting and functionality of the nanoconstructs. This study sought to overcome that challenge through a systematic approach of gold nanorod (GNR) functionalization: evaluating the influence of both aspect ratio and surface chemistry on targeted cellular internalization rates and preservation of particle integrity. Owing to their unique spectral properties and enhanced surface area, GNRs possess great potential for the advancement of nanobased delivery and imaging applications. However, their ability for efficient intracellular delivery while maintaining their specific physiochemical parameters has yet to be satisfactorily explored. This study identified that longer and positively charged GNRs demonstrated a higher degree of internalization compared to their shorter and negative counterparts. Notably, of the four surface chemistries explored, only tannic acid resulted in retention of GNR integrity following endocytosis into keratinocyte cells, due to the presence of a strong protein corona matrix that served to protect the particles.
Taken together, these results identify tannic acid functionalized GNRs as a potential candidate for future development in nanobased biomolecule delivery, bioimaging, and therapeutic applications.
Inclusive pages
8366–8373
ISBN/ISSN
1944-8244
Document Version
Postprint
Copyright
Copyright © 2013, American Chemical Society
Publisher
American Chemical Society
Volume
5
Peer Reviewed
yes
Issue
17
Sponsoring Agency
Dayton Area Graduate Studies Institute; Oak Ridge Institute for Science and Education (ORISE); Henry Jackson Foundation
eCommons Citation
Untener, Emily A.; Comfort, Kristen K.; Maurer, Elizabeth I.; Grabinski, Christin M.; Comfort, Donald A.; and Hussain, Saber M., "Tannic Acid Coated Gold Nanorods Demonstrate a Distinctive Form of Endosomal Uptake and Unique Distribution within Cells" (2013). Chemical and Materials Engineering Faculty Publications. 171.
https://ecommons.udayton.edu/cme_fac_pub/171
Included in
Other Chemical Engineering Commons, Other Materials Science and Engineering Commons, Petroleum Engineering Commons, Polymer and Organic Materials Commons, Thermodynamics Commons
Comments
This document available for download is the authors' accepted manuscript, provided in compliance with the publisher's policy on self-archiving. Some differences may exist between this document and the version of record.
Permission documentation is on file.