Effect of Particle Dimension on Biocompatibility of Carbon Nanomaterials
Document Type
Article
Publication Date
11-2007
Publication Source
Carbon
Abstract
With various emerging applications ranging from medicine to materials and electronics, the risk of exposure to nanomaterials is rapidly increasing. Several routes of exposure to nanomaterials exist; the most important being dermal contact and inhalation. In this dermal toxicity study, the cellular effects of carbon-based materials with diameters ranging from micro- to nano-dimension were investigated using mouse keratinocytes (HEL-30). The carbon materials tested included carbon fibers (CF; 10 μm diameter), carbon nanofibers (CNF; 100 nm diameter), multi-walled carbon nanotubes (MWCNT; 10 nm diameter), and single-walled carbon nanotubes (SWCNT; 1 nm diameter). CF and CNF did not significantly affect cell viability; however, MWCNT and SWCNT reduced cell viability in a time-dependent manner up to 48 h, with full recovery of mitochondrial function by the 72 h time point. After a 24 h exposure, cells exposed to MWCNT produced up to 3-fold higher increase in reactive oxygen species than those exposed to SWCNT. The results of this study suggest that high-aspect ratio carbon material toxicity is dependent on dimension and composition.
Inclusive pages
2828–2835
ISBN/ISSN
0008-6223
Copyright
Copyright © 2007, Elsevier
Publisher
Elsevier
Volume
45
Peer Reviewed
yes
Issue
14
eCommons Citation
Grabinski, Christin; Hussain, Saber M.; Lafdi, Khalid; Braydich-Stolle, Laura; and Schlager, John J., "Effect of Particle Dimension on Biocompatibility of Carbon Nanomaterials" (2007). Chemical and Materials Engineering Faculty Publications. 46.
https://ecommons.udayton.edu/cme_fac_pub/46
