Title

Tep1 Regulates Yki Activity in Neural Stem Cells in Drosophila Glioma Model

Authors

Karishma Gangwani, University of DaytonFollow

Date

4-22-2021

Files

Description

Glioblastoma is the most common form of malignant brain tumor with a poor prognosis. Using a Drosophila glioma model, we showed that the Drosophila Tep1 gene (human CD109) regulates Yki (human YAP/TAZ) via an evolutionarily conserved mechanism. Oncogenic signaling by the YAP/TAZ pathway occurs in cells that acquire CD109 expression. Loss of Tep1 caused a reduction in glioma growth. Further, Tep1 affects Yki mediated stem cell renewal in glioma, as reduction of Tep significantly decreases the number of neuroblasts in glioma. Thus, we identify Tep1-Yki interaction in the larval CNS that plays a key role in glioma growth and progression.

Academic Advisor

Madhuri Kango-Singh

Academic Department(s)

Biology

Degree Pursued

Doctorate

Recommended Citation

Gangwani, Karishma, "Tep1 Regulates Yki Activity in Neural Stem Cells in Drosophila Glioma Model" (2021). Graduate Student Showcase. 3.
https://ecommons.udayton.edu/grad_showcase/3