Skeletal Muscle Adaptations Following Spinal Cord Contusion Injury in Rat and the Relationship to Locomotor Function: A Time Course Study

Author(s)

Karen J. Hutchinson, Northeastern University
Jon K. Linderman, University of DaytonFollow
D. Michele Basso, Ohio State University - Main Campus

Document Type

Article

Publication Date

7-8-2004

Publication Source

Journal of Neurotrauma

Abstract

Experimental spinal cord injury (SCI) via contusion of moderate severity results in residual locomotor deficits, including a lack of coordination and trunk stability. Given that muscle contractile properties and fiber composition adapt to reduced neural input and/or weight bearing, contusioninduced locomotor deficits may reflect changes in hindlimb skeletal muscle. Therefore, we examined muscle adaptations during early (1 week), intermediate (3 week), and late (10 week) stages of motor recovery after moderate SCI. Forty-two Sprague Dawley rats underwent SCI via 1.1mm cord displacement with the OSU impact device or served as age and weight-matched or laminectomy controls. Subsets of rats had soleus (SOL) in vitro physiological testing or SOL and extensor digitorum longus (EDL) myosin heavy chain (MHC) fiber type analysis. At 1 week post-SCI during paralysis/paresis, a significant decrease in wet weight occurred in the plantaris, medial/lateral gastrocnemius (MG/LG), tibialis anterior, and SOL. Changes in contractile properties of the SOL did not accompany muscle wet weight changes. By 3 weeks, the loss of weight-bearing activity early after SCI induced significant decreases in SOL peak twitch and peak tetanic tension as well as significantly greater IIx MHC expression in the EDL. By 10 weeks post-SCI, after several weeks of weight supported stepping, muscle wet weight, contractile properties and MHC composition returned to baseline levels except for MG/LG atrophy. Thus, muscle plasticity appears to be extremely sensitive to locomotor deficits and their resolution after moderate spinal cord contusion.

Inclusive pages

1075-1089

ISBN/ISSN

0897-7151

Comments

Permission documentation on file.

Copyright

Copyright © 2004, Mary Ann Liebert

Publisher

Mary Ann Liebert

Volume

18

Issue

10

Peer Reviewed

yes

eCommons Citation

Hutchinson, Karen J.; Linderman, Jon K.; and Basso, D. Michele, "Skeletal Muscle Adaptations Following Spinal Cord Contusion Injury in Rat and the Relationship to Locomotor Function: A Time Course Study" (2004). Health and Sport Science Faculty Publications. 82.
https://ecommons.udayton.edu/hss_fac_pub/82