Stimulation of Myofibrillar Protein Synthesis in Hindlimb Suspended Rats by Resistance Exercise and Growth Hormone

Author(s)

Jon K. Linderman, University of DaytonFollow
Justen B. Whittall, NASA/Ames Research Center
Kristin L. Gosselink, University of Arizona
Tommy J. Wang, NASA/Ames Research Center
Venkat R. Mukku, Genentech Inc.
Frank W. Booth, University of Texas
Richard E. Grindeland, University of Arizona

Document Type

Article

Publication Date

7-14-1995

Publication Source

Life Sciences

Abstract

The objective of this study was to determine the ability of a single bout of resistance exercise alone or in combination with recombinant human growth hormone (rhGH) to stimulate myofibrillar protein synthesis (Ks) in hindlimb suspended (HLS) adult female rats. Plantar flexor muscles were stimulated with resistance exercise, consisting of 10 repetitions of ladder climbing on a 1m grid (85 °), carrying an additional 50% of their body weight attached to their tails. Saline or rhGH (1 mg/kg) was administered 30′ prior to exercise, and Ks was determined with a constant infusion of 3H-Leucine at 15′, 60′, 180′, and 360′ following exercise. Three days of HLS depressed Ks 6̃5% and 30–40% in the soleus and gastrocnemius muscles, respectively (p

Inclusive pages

755-762

ISBN/ISSN

0024-3205

Comments

Permission documentation on file.

Copyright

Copyright © 1995, Elsevier

Publisher

Elsevier

Volume

57

Issue

8

Peer Reviewed

yes

eCommons Citation

Linderman, Jon K.; Whittall, Justen B.; Gosselink, Kristin L.; Wang, Tommy J.; Mukku, Venkat R.; Booth, Frank W.; and Grindeland, Richard E., "Stimulation of Myofibrillar Protein Synthesis in Hindlimb Suspended Rats by Resistance Exercise and Growth Hormone" (1995). Health and Sport Science Faculty Publications. 92.
https://ecommons.udayton.edu/hss_fac_pub/92