Title

Effects of Cell Cycle Noise on Excitable Gene Circuits

Author(s)

Alan Veliz-Cuba, University of DaytonFollow
Chinmaya Gupta, University of Houston
Matthew R. Bennett, Rice University
Krešimir Josić, University of Houston
William Ott, University of Houston

Document Type

Article

Publication Date

11-30-2016

Publication Source

Physical Biology

Abstract

We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a three-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks.

ISBN/ISSN

1478-3967

Document Version

Postprint

Comments

This is an author-created, un-copyedited version of an article accepted for publication/published in Physical Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. To view the version of record, use the DOI provided.

Permission documentation on file.

Copyright

Copyright © 2016, IOP Publishing Ltd

Publisher

IOP Publishing

Volume

13

Issue

6

Peer Reviewed

yes

Keywords

Bistable switch, cell cycle noise, excitable system, metastability, synthetic genetic oscillator, transcriptional delay

eCommons Citation

Veliz-Cuba, Alan; Gupta, Chinmaya; Bennett, Matthew R.; Josić, Krešimir; and Ott, William, "Effects of Cell Cycle Noise on Excitable Gene Circuits" (2016). Mathematics Faculty Publications. 82.
https://ecommons.udayton.edu/mth_fac_pub/82