Document Type
Article
Publication Date
11-30-2016
Publication Source
Physical Biology
Abstract
We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a three-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks.
ISBN/ISSN
1478-3967
Document Version
Postprint
Copyright
Copyright © 2016, IOP Publishing Ltd
Publisher
IOP Publishing
Volume
13
Issue
6
Peer Reviewed
yes
Keywords
Bistable switch, cell cycle noise, excitable system, metastability, synthetic genetic oscillator, transcriptional delay
eCommons Citation
Veliz-Cuba, Alan; Gupta, Chinmaya; Bennett, Matthew R.; Josić, Krešimir; and Ott, William, "Effects of Cell Cycle Noise on Excitable Gene Circuits" (2016). Mathematics Faculty Publications. 82.
https://ecommons.udayton.edu/mth_fac_pub/82
Included in
Applied Mathematics Commons, Biology Commons, Cell and Developmental Biology Commons, Mathematics Commons, Statistics and Probability Commons
Comments
This is an author-created, un-copyedited version of an article accepted for publication/published in Physical Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. To view the version of record, use the DOI provided.
Permission documentation on file.