N-t-Boc-amino Acid Esters of Isomannide: Potential Inhibitors of Serine Proteases

Author(s)

Estela M.F. Muri, Universidade do Brasil
Marlito Gomes Jr., Universidade do Brasil
J. S. Costa, Federal University of Rio de Janeiro
F. L. Alencar, Federal University of Rio de Janeiro
A. Sales Jr., Federal University of Rio de Janeiro
Marcelo L. Bastos, Federal University of Rio de Janeiro
Ricardo Hernández Valdés, Federal University of Rio de Janeiro
Magaly Girão Albuquerque, Universidade do Brasil
Elaine F. F. da Cunha, Universidade do Brasil
Ricardo Bicca de Alencastro, Universidade do Brasil
John S. Williamson, University of DaytonFollow
Octavio A.C. Antunes, Universidade do Brasil

Document Type

Article

Publication Date

10-2004

Publication Source

Amino Acids

Abstract

Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors.

Inclusive pages

153–159

ISBN/ISSN

0939-4451

Comments

Permission documentation is on file.

Copyright

Copyright © 2004, Springer-Verlag/Wien

Publisher

Springer

Volume

27

Issue

2

Peer Reviewed

yes

eCommons Citation

Muri, Estela M.F.; Gomes, Marlito Jr.; Costa, J. S.; Alencar, F. L.; Sales, A. Jr.; Bastos, Marcelo L.; Hernández Valdés, Ricardo; Albuquerque, Magaly Girão; da Cunha, Elaine F. F.; de Alencastro, Ricardo Bicca; Williamson, John S.; and Antunes, Octavio A.C., "N-t-Boc-amino Acid Esters of Isomannide: Potential Inhibitors of Serine Proteases" (2004). Office for Research Publications and Presentations. 14.
https://ecommons.udayton.edu/ofr_pub/14