Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger

Author(s)

Igor A. Parshikov, University of Mississippi
Bruhaspathy Miriyala, University of Mississippi
Mitchell A. Avery, University of Mississippi
John S. Williamson, University of DaytonFollow

Document Type

Article

Publication Date

4-2004

Publication Source

Biotechnology Letters

Abstract

The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 °C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l⁻¹) to 15-hydroxy-10-deoxoartemisinin (26%) and 7β-hydroxy-10-deoxoartemisinin (69%).

Inclusive pages

607–610

ISBN/ISSN

0141-5492

Comments

Permission documentation is on file.

Copyright

Copyright © 2004, Kluwer Academic Publishers

Publisher

Springer

Volume

26

Issue

7

Peer Reviewed

yes

eCommons Citation

Parshikov, Igor A.; Miriyala, Bruhaspathy; Avery, Mitchell A.; and Williamson, John S., "Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger" (2004). Office for Research Publications and Presentations. 19.
https://ecommons.udayton.edu/ofr_pub/19