Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger
The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 °C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l−1) to 15-hydroxy-10-deoxoartemisinin (26%) and 7β-hydroxy-10-deoxoartemisinin (69%).
Copyright © 2004, Kluwer Academic Publishers
Parshikov, Igor A.; Miriyala, Bruhaspathy; Avery, Mitchell A.; and Williamson, John S., "Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger" (2004). Office for Research Publications and Presentations. 19.