Biotransformation of 10-deoxoartemisinin to its 7β-hydroxy Derivative by Mucor ramannianus
10-Deoxoartemisinin at 0.2 mg ml−1 medium was transformed to 7β-hydroxy deoxoartemisinin by Mucor ramannianus growing on sucrose, 20 g l−1, and peptone, 10 g l−1, at pH 4 and 26 °C. The yield of product was increased from 16% to 45% by selecting optimal culture conditions using a 25−2 factorial design.
Copyright © 2002, Kluwer Academic Publishers
Fiaux de Medeiros, Sorele; Avery, Mitchell A.; Avery, Bonnie A.; Leite, Selma G.F.; Freitas, Antonio Carlos C.; and Williamson, John S., "Biotransformation of 10-deoxoartemisinin to its 7β-hydroxy Derivative by Mucor ramannianus" (2002). Office for Research Publications and Presentations. 25.