A Review of Cancer Chemopreventive Agents
Document Type
Article
Publication Date
2001
Publication Source
Current Medicinal Chemistry
Abstract
In the late 20th century, the treatment of cancer began to include its prevention. Today, compounds exist that will lower the risk of developing certain types of cancer. This has been demonstrated in studies where chemically induced tumor growth has been slowed or reversed. Anti-inflammatory compounds having chemopreventive activity are piroxicam, sulindac, aspirin, celecoxib and curcumin. The selective estrogen receptor modulators, tamoxifen and raloxifene, are beneficial in the prevention of estrogendependent tumors. Retinoids, vitamin A derivatives, such as targretin and fenretinide are useful in the prevention of tumors. Compounds containing sulfur, such as sulforaphane and oltipraz, are even useful as radioprotective agents. The steroid dehydroepiandosterone can inhibit experimental carcinogenesis. All of these chemical classes provide a start for the medicinal chemist to design more effective chemopreventive agents. The biomarkers used to determine the chemopreventive activity of new compounds are quite often activities of enzymes. The identification of those individuals at high risk is still in its infancy and presents a troubling dilemma.
Inclusive pages
1349-1362
ISBN/ISSN
0929-8673
Copyright
Copyright © 2001, Bentham Science Publishers
Publisher
Bentham Science Publishers
Volume
8
Issue
11
Peer Reviewed
yes
eCommons Citation
Levi, Mark S.; Borne, Ronald F.; and Williamson, John S., "A Review of Cancer Chemopreventive Agents" (2001). Office for Research Publications and Presentations. 29.
https://ecommons.udayton.edu/ofr_pub/29
Comments
Permission documentation is on file.