Physics Faculty Publications
Document Type
Article
Publication Date
6-22-2017
Publication Source
Journal of Nanophotonics
Abstract
Single-molecule detection has become a unique and indispensable tool for the study of molecular motions and interactions at the single-molecule level. Unlike ensemble measurement where the information is averaged, single-molecule analysis yields invaluable information on both the individual molecular properties and their microenvironment. Among the various technologies for the detection of single molecules, the detection with optical methods has many advantages in terms of its high sensitivity, electrical passiveness, and robustness. The recent advances in the engineering of either the excitation light or the solution of the molecules have paved the way for enhanced single-molecule detection. We present recent developments and future perspectives for single-molecule detection in the following three regimes: on a dry surface, in solutions at ultralow concentrations, and in solutions at native physiological concentrations.
Inclusive pages
012504-1:012504-15
ISBN/ISSN
1934-2608
Document Version
Published Version
Copyright
Copyright © 2017, Society of Photo Optical Instrumentation Engineers (SPIE)
Publisher
Society of Photo Optical Instrumentation Engineers (SPIE)
Volume
12
Issue
1
Peer Reviewed
yes
eCommons Citation
Karim, Farzia; Smith, Todd B.; and Zhao, Chenglong, "Review of Optical Detection of Single Molecules Beyond the Diffraction and Diffusion Limit Using Plasmonic Nanostructures" (2017). Physics Faculty Publications. 38.
https://ecommons.udayton.edu/phy_fac_pub/38
Comments
DOI: https://doi.org/10.1117/1.JNP.12.012504.
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