Presenter(s)

Glenna M. Knape

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Description

The Eastern Newt, Notophthalamus viridescens, has regenerative abilities. This study delved into the ability of the newt to regenerate the lens of its eye from the iris following a lentectomy surgery. To regenerate, the dorsal and ventral regions of the iris dedifferentiate and proliferate, yet only the dorsal iris redifferentes to create a lens, rather than both the dorsal and ventral iris. Several candidate transposons, or sections of viral DNA incorporated into another organismâÂÂs genome, were selected from a transcriptome to study. In order to compare the differences between the dorsal and ventral irises, the candidate genesâ expression levels were monitored in regenerating lens at 0, 4, and 8 day time points following the surgery. The expression levels were compared to determine whether they are correlated with the regenerative ability. A further understanding of the newtâÂÂs regenerative abilities as a model organism could lead to groundbreaking advances in regenerative biology and medicine.

Publication Date

4-18-2012

Project Designation

Honors Thesis

Primary Advisor

Panagiotis A. Tsonis

Primary Advisor's Department

Biology

Keywords

Stander Symposium project

Comparison of Notophthalamus viridescens Transposon Expression in the Dorsal and Ventral Iris during Lens Regeneration

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