Presenter(s)

    Parker Maddison Griff

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    Description

    Early life stress is a risk factor for later development of alcohol use disorders and anxiety disorders in humans. Using rodent experimental models, we know that rats experiencing social isolation as early-life stress exhibit greater anxiety-like behavior and alcohol consumption than rats housed in groups. Examining potential preventive strategies, we investigated the effects of probiotics, which have previously been shown to decrease rodent anxiety-like behavior, on the relationship between early-life stress and anxiety-like behavior in rats. We hypothesized that probiotics consumption would decrease anxiety-like behavior in socially isolated rats, as well as in rats housed in groups. To our surprise, we found that the probiotics had no significant effect on anxiety-like behavior for socially isolated rats but significantly increased anxiety-like behavior in rats housed in groups. Our results suggest probiotics do not have a positive benefit to alleviate consequences of early life stress and raise caution for their therapeutic use.

    Publication Date

    4-18-2018

    Project Designation

    Honors Thesis

    Primary Advisor

    Tracy R. Butler, Yvonne Y. Sun

    Primary Advisor's Department

    Psychology

    Keywords

    Stander Symposium project

    Chronic administration of probiotic L. rhamnosus increases anxiety-like behavior in group-housed male Long Evans rats

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