Chronic Administration of the Novel SERCA2 Activator CDN1163 Induces Behavioral and Neurochemical Effects in Mice.

Chronic Administration of the Novel SERCA2 Activator CDN1163 Induces Behavioral and Neurochemical Effects in Mice.

    Presenter(s)

    Aikaterini Britzolaki

    Description

    Intracellular calcium homeostasis is essential for neuronal function and survival, with the endoplasmic reticulum (ER) being a major internal calcium reservoir. Our group focuses on the sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) pump that is a pivotal regulator of cytosolic calcium levels. Compelling evidence indicates that these P-type ATPases play a critical role in brain pathophysiology. Hence, SERCA pumps comprise an emerging pharmacological target for debilitating brain diseases. Interestingly, studies suggest that a novel SERCA activator, namely CDN1163, may rescue motor and cognitive dysfunction in rodent models of Alzheimer’s and Parkinson’s diseases. As little is known about the behavioral and neurochemical consequences of CDN1163 administration, in the context of this study, we are presenting the effects of acute and chronic CDN1163 administration on locomotor activity and relevant affective behaviors, as well as on monoaminergic neurotransmission in naïve C57BL/6J mice of both sexes.

    Publication Date

    4-22-2021

    Project Designation

    Graduate Research

    Primary Advisor

    Pothitos Pitychoutis

    Primary Advisor's Department

    Biology

    Keywords

    Stander Symposium project, College of Arts and Sciences

    United Nations Sustainable Development Goals

    Good Health and Well-Being

    Chronic Administration of the Novel SERCA2 Activator CDN1163 Induces Behavioral and Neurochemical Effects in Mice.

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