Uncovering the Role of the Central Nervous System in Salamander Regeneration

Uncovering the Role of the Central Nervous System in Salamander Regeneration

Presenter(s)

Ben Klocke, Augustine J. Miller, Jason Andrew Tornes

Description

Limb loss is a significant and debilitating health issue, affecting almost 2 million citizens in the United States alone. Unlike humans, the axolotl Ambystoma mexicanum possesses the remarkable ability to regenerate entire limbs and organs following amputation. The nervous system is known to play a critical role in regeneration, as intact peripheral nerves are necessary for proper limb regeneration. However, the role of the brain in regulating this fascinating process is unknown. In order to uncover the role of the brain in limb regeneration, we have conducted a series of neurochemical studies using high-performance liquid chromatography (HPLC), as well as a high-throughput proteomics analysis to identify the neuromolecular processes affected in the axolotl brain during the course of limb regeneration. Taken together, these experimental data will contribute to ongoing studies by our group aiming to uncover the neuromolecular mechanisms underlying the role of the brain in amphibian regeneration.

Publication Date

4-22-2021

Project Designation

Graduate Research

Primary Advisor

Pothitos Pitychoutis

Primary Advisor's Department

Biology

Keywords

Stander Symposium project, College of Arts and Sciences

United Nations Sustainable Development Goals

Good Health and Well-Being

Uncovering the Role of the Central Nervous System in Salamander Regeneration

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