Investigating the Role of Neural Stem Cells in Aggressive Gliomas
Sadie Mae Salamone
Glioblastoma Multiforme (GBM) is an extremely aggressive type of brain cancer with no ultimate cure and a high mortality rate. These tumors form and metastasize quickly, making this specific type of cancer difficult to treat and fatal for almost all who receive this diagnosis. This study will explore the growth patterns of GBM tumors using the model organism of Drosophila melanogaster, which is the common fruit fly. A genetic cross between two genotypically different flies is used to produce the GBM tumor. These genotypes represent mutations in genes commonly found mutated in human patients, thus findings from this work may be relevant to understanding early changes in glial cells in human glia as well. The findings from this study will allow for a better understanding of the growth patterns of GBM tumors and hopefully aid in finding a treatment method for this aggressive type of cancer. The purpose of this poster is to discuss the dangers of GBM, discuss the fruit fly as a model organism, describe completed and planned steps of this investigation and explore the benefits and possible ramifications that may arise in this study.
Madhuri Kango-Singh, Kathleen C. Scheltens
Primary Advisor's Department
Stander Symposium project, College of Arts and Sciences
United Nations Sustainable Development Goals
"Investigating the Role of Neural Stem Cells in Aggressive Gliomas" (2022). Stander Symposium Projects. 2412.