Presenter(s)

Marika S. Edwards, Dillon T. Grandinette, Branden J. King, Jonathan B. Melendez

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Description

This study focuses on the engineering and design of a biconic, tapered optical fiber platform for biosensing applications. The sensor platform consists of a machined polytetrafluoroethylene (Teflon, PTFE) flow cell which is chemically inert, easily machined, and available at low-cost. The flow cell was designed to withstand temperatures of 0 to 60 degrees Celsius, to protect the fragile, tapered fiber, and connected to a syringe pump to allow for the introduction of aqueous solutions for surface chemistry functionalization and analyte exposures. The flow system was used to characterize individual single-mode or polarization-maintaining fibers that were tapered to a waist diameter of approximately 10 microns. Signal was measured as the amount of light transmission through the tapered fibers. Preliminary results obtained for antibody-antigen interactions indicate that molecular interaction of the antigen with the surface-tethered antibody results in a change in the quantity and phase of light passing through the tapered fiber.

Publication Date

4-17-2013

Project Designation

Independent Research

Primary Advisor

Karolyn M. Hansen

Primary Advisor's Department

Biology

Keywords

Stander Symposium project

Fabrication of Low-Cost Flow Cell and Tapered Optical Fibers for Aqueous Biosensing

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