![Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice](https://ecommons.udayton.edu/stander_posters/3854/thumbnail.jpg)
Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice
Presenter(s)
Ben Klocke, Carter Moore
Files
Description
Calcium ions (Ca2+) in the brain play a vital role in prominent neurobiological functions, including neural communication, growth, long-term potentiation, and cell death. As a result, the regulation of Ca2+ levels in neurons is carefully managed, and Ca2+ dysregulation has been linked to various neuropsychiatric disorders including Alzheimer's disease, Parkinson's disease, and Schizophrenia. Herein, we sought to investigate how chronic pharmacological activation of an integral endoplasmic reticulum Ca2+-handling effector may affect learning and memory in the Morris Water Maze test in C57BL/6J mice of both sexes. In the context of the current honors thesis, we have gained insights into the relationship between intracellular Ca2+ homeostasis and learning and memory processes. Our efforts are currently targeted towards extending our findings in additional animal models of learning and memory.
Publication Date
4-19-2023
Project Designation
Honors Thesis
Primary Advisor
Pothitos Pitychoutis
Primary Advisor's Department
Biology
Keywords
Stander Symposium, College of Arts and Sciences
Institutional Learning Goals
Scholarship; Practical Wisdom
Recommended Citation
"Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice" (2023). Stander Symposium Projects. 2853.
https://ecommons.udayton.edu/stander_posters/2853
![Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice](https://ecommons.udayton.edu/stander_posters/3854/thumbnail.jpg)
Comments
Presentation: 1:40-2:00 p.m., Kennedy Union 207