Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice

Authors

Presenter(s)

Ben Klocke, Carter Moore

Comments

Presentation: 1:40-2:00 p.m., Kennedy Union 207

Files

Description

Calcium ions (Ca2+) in the brain play a vital role in prominent neurobiological functions, including neural communication, growth, long-term potentiation, and cell death. As a result, the regulation of Ca2+ levels in neurons is carefully managed, and Ca2+ dysregulation has been linked to various neuropsychiatric disorders including Alzheimer's disease, Parkinson's disease, and Schizophrenia. Herein, we sought to investigate how chronic pharmacological activation of an integral endoplasmic reticulum Ca2+-handling effector may affect learning and memory in the Morris Water Maze test in C57BL/6J mice of both sexes. In the context of the current honors thesis, we have gained insights into the relationship between intracellular Ca2+ homeostasis and learning and memory processes. Our efforts are currently targeted towards extending our findings in additional animal models of learning and memory.

Publication Date

4-19-2023

Project Designation

Honors Thesis

Primary Advisor

Pothitos Pitychoutis

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Institutional Learning Goals

Scholarship; Practical Wisdom

Recommended Citation

"Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice" (2023). Stander Symposium Projects. 2853.
https://ecommons.udayton.edu/stander_posters/2853