Ruthenium-BODIPY Complexes as Potential Photodynamic Therapy Agents

Ruthenium-BODIPY Complexes as Potential Photodynamic Therapy Agents

Presenter(s)

Jake Swavey, Darcy Setter, Frederick Willits

Comments

Presentation: 9:00-10:15 a.m., Kennedy Union Ballroom

Description

Photodynamic therapy is a process by which light, a photosensitizer, and molecular oxygen are utilized to generate reactive oxygen species in a targeted microenvironment. The project presented will describe the synthesis of three new 4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dyes capable of strong absorption within the visible region of the spectrum. Incorporated within these dyes are conjugating Lewis Bases capable of coordinating to Ruthenium(II) complexes. There synthesis and characterization along with their ability to photo-react with plasmid DNA when irradiated with low energy light will be presented.

Publication Date

4-19-2023

Project Designation

Independent Research

Primary Advisor

Shawn Swavey

Primary Advisor's Department

Chemistry

Keywords

Stander Symposium, College of Arts and Sciences

Ruthenium-BODIPY Complexes as Potential Photodynamic Therapy Agents

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