Presenter(s)

    Ben Klocke, Hayden Ott

    Comments

    Presentation: 9:00-10:15 a.m., Kennedy Union Ballroom

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    Description

    Calcium (Ca2+) is a critical ionic messenger implicated in a wide variety of cellular processes including gene transcription, muscle contraction, and neurotransmitter release. A Ca2+-handling player of particular interest is the sarco-endoplasmic reticulum Ca2+ ATPase (SERCA), an intracellular regulator of Ca2+ homeostasis that functions by sequestering Ca2+ into the endoplasmic reticulum (ER). Indeed, previous research has implicated dysfunction of SERCA regulation as a contributor to neurodegenerative diseases such as Alzheimer’s disease and neurodevelopmental disorders including Autism-spectrum disorder (ASD). In the current study, we sought to investigate how chronic pharmacological activation of SERCA may affect executive functioning in mice. Mice of both sexes were chronically administered the small allosteric SERCA activator CDN1163 and were then subjected to behavioral testing by use of the five-choice serial reaction time test (5CSRTT), a learned task that can be used to assess behaviors including attention and impulsivity. The results of this study contribute to our ongoing investigations into the behavioral and neurobiological mechanisms implicating SERCA in the underlying mechanisms of complex neurodegenerative and neurodevelopmental disorders.

    Publication Date

    4-19-2023

    Project Designation

    Independent Research

    Primary Advisor

    Pothitos Pitychoutis

    Primary Advisor's Department

    Biology

    Keywords

    Stander Symposium, College of Arts and Sciences

    Institutional Learning Goals

    Scholarship; Practical Wisdom

    Using the Five-Choice Serial Reaction Time Test (5CSRTT) to Assess the Behavioral Impact of Chronic SERCA Activation in Mice

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