Identification Of miRNA in Growth And Survival

Identification Of miRNA in Growth And Survival

Presenter(s)

Prajakta Deshpande, Esther Labya; other author: Amit Singh

Comments

Presentation: 1:15-2:30 p.m., Kennedy Union Ballroom

Description

Cell size is essential in a cell's cellular processes and function. Hence cell size andgrowth need to be appropriately maintained. Gene regulation plays a vital role inregulating gene expression of different cellular processes like apoptosis, cell growth,etc. MicroRNAs (miRNAs), small single-stranded RNAs, regulate gene expression post-transcriptionally by binding to the 3’ untranslated region (UTR) of their target messengerRNAs (mRNAs), degrade their target mRNA, and hence silence their gene expression.In a forward genetic screen, our lab has identified a micro-RNA that inhibits apoptosisin the Drosophila eye model. Previous study shows that in the hippo (hpo) mutantsexhibit overgrowth, whereas gain-of-function of hippo triggers cell death in thedeveloping eye. Our preliminary data suggest that the gain-of-function of miR-277 in theGMR>hpo background rescues Hpo-mediated cell death. In addition, the gain-of-function of miRNA-277 restores the impaired axonal targeting observed in GMR>hpoeye disc. Hence, our working model suggests that miRNA regulates cell growth bymodulating the hippo pathway.

Publication Date

4-19-2023

Project Designation

Independent Research

Primary Advisor

Amit Singh

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Institutional Learning Goals

Scholarship

Identification Of miRNA in Growth And Survival

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