Unveiling the role of Hippo Interactors in Glioma Progression in Drosophila glioma model.
Presenter(s)
Satya Burugupalli, Arushi Rai
Files
Description
Signalling interactions play an important role in tumorigenesis. The Hippo signalling pathway originally identified for its role in organ size maintenance also plays a key role in tumor progression. Using the previously published Drosophila glioma model in which coactivation the EGFR receptor and Phospho-inositol 3 kinase (PI3K) pathways in the CNS glia using repoGAL4, we plan to study the role of interactions of Yorkie (YAP/TAZ in human), the downstream effector of the Hippo pathway, with other pathways in promotion of glioma growth. Given the conservation of genes and cell biological pathways, finding from our studies are expected to be extrapolated to higher vertebrates. Initial studies showed the role of Yorkie in neural stem cells in the growth of glioma. Here we present our progress with evaluating the role of other Yki interacting pathways using immunostaining, western blots and qPCR analyses to investigate which pathways are important for glioma progression.
Publication Date
4-17-2024
Project Designation
Graduate Research
Primary Advisor
Madhuri Kango-Singh, Amit Singh
Primary Advisor's Department
Biology
Keywords
Stander Symposium, College of Arts and Sciences
Recommended Citation
"Unveiling the role of Hippo Interactors in Glioma Progression in Drosophila glioma model." (2024). Stander Symposium Projects. 3593.
https://ecommons.udayton.edu/stander_posters/3593
Comments
Presentation: 10:45-12:00, Kennedy Union Ballroom