Unveiling the role of Hippo Interactors in Glioma Progression in Drosophila glioma model.

Unveiling the role of Hippo Interactors in Glioma Progression in Drosophila glioma model.

Presenter(s)

Satya Burugupalli, Arushi Rai

Comments

Presentation: 10:45-12:00, Kennedy Union Ballroom

Description

Signalling interactions play an important role in tumorigenesis. The Hippo signalling pathway originally identified for its role in organ size maintenance also plays a key role in tumor progression. Using the previously published Drosophila glioma model in which coactivation the EGFR receptor and Phospho-inositol 3 kinase (PI3K) pathways in the CNS glia using repoGAL4, we plan to study the role of interactions of Yorkie (YAP/TAZ in human), the downstream effector of the Hippo pathway, with other pathways in promotion of glioma growth. Given the conservation of genes and cell biological pathways, finding from our studies are expected to be extrapolated to higher vertebrates. Initial studies showed the role of Yorkie in neural stem cells in the growth of glioma. Here we present our progress with evaluating the role of other Yki interacting pathways using immunostaining, western blots and qPCR analyses to investigate which pathways are important for glioma progression.

Publication Date

4-17-2024

Project Designation

Graduate Research

Primary Advisor

Madhuri Kango-Singh, Amit Singh

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Unveiling the role of Hippo Interactors in Glioma Progression in Drosophila glioma model.

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