Antagonistic interactions between Dpp signaling and defective proventriculus determines eye versus head fate

Antagonistic interactions between Dpp signaling and defective proventriculus determines eye versus head fate

Presenter(s)

Anjali Sangeeth

Comments

Presentation: 1:15-2:30, Kennedy Union Ballroom

Description

Axial patterning, a crucial process during development, involves the delineation of three axes, such as Antero-Posterior (AP), Dorso-Ventral (DV), and Proximo-Distal (PD), is required for the transition of a monolayer organ primordium to a three-dimensional organ.Axial patterning involves the participation of morphogens, transcription factors, and regulatory genes. Any deviations in this process result in birth defects. We have identified a K-50 homeodomain-containing transcription factor, defective proventriculus (dve, an ortholog of SATB1), as a dorsal fate selector gene during eye development. Using genetic approaches, we found that Dve interacts with various signaling pathways during eye development to determine eye versus head fate. Among these, a highly conserved Decapentaplegic (Dpp)/Bone Morphogenetic Protein (BMP) signaling pathway, which forms a morphogen gradient in the developing Drosophila eye, acts antagonistically to dve to regulate retinal differentiation and thereby determines eye versus head fate. Here we present our studies on molecular genetic interactions between the members of Dpp signaling pathway and dve during eye development. Interestingly, SATB1, a mammalian homolog of dve, exhibits similar interaction with Dpp signaling pathway members suggesting that these interactions may be conserved.

Publication Date

4-17-2024

Project Designation

Graduate Research

Primary Advisor

Amit Singh

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Antagonistic interactions between Dpp signaling and defective proventriculus determines eye versus head fate

Share

COinS