Assessing the behavioral effects of pharmacological SERCA activation in the dizolpine-induced mouse model of psychosis

Assessing the behavioral effects of pharmacological SERCA activation in the dizolpine-induced mouse model of psychosis

Presenter(s)

Erin Flaherty, Hayden Ott

Comments

9:00-10:15, Kennedy Union Ballroom

Description

Intracellular calcium (Ca2+) homeostasis plays a critical role in a variety of neural processes including neurotransmission, development, and apoptosis. The sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) is a Ca2+-handling regulator that sequesters cytosolic Ca2+ into the neuron's smooth endoplasmic reticulum. Notably, disruption of mechanisms that are responsible for maintaining Ca2+ homeostasis has been implicated in the pathophysiology of neuropsychiatric disorders such as Schizophrenia. In the context of the current study, our lab sought to investigate the effects of chronic pharmacological SERCA activation via administration of CDN1163, an allosteric activator of SERCA, on the dizocilpine (MK801)-induced mouse model of psychosis. Male and female mice of the C57BL/6J strain were chronically treated with daily intraperitoneal injections of CDN1163 and their locomotor activity was assessed upon acute dizocilpine administration. The results of this study provide us with a better understanding of SERCA's role in behavior as well as its putative implication in the neurobiology of schizophrenia.

Publication Date

4-23-2025

Project Designation

Honors Thesis

Primary Advisor

Dorian Borbonus, Pothitos Pitychoutis

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Institutional Learning Goals

Scholarship

Assessing the behavioral effects of pharmacological SERCA activation in the dizolpine-induced mouse model of psychosis

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