A new BODIPY photosensitizer capable of excitation within the near-infrared (NIR) region of the electromagnetic spectrum

A new BODIPY photosensitizer capable of excitation within the near-infrared (NIR) region of the electromagnetic spectrum

    Presenter(s)

    Emily Hardie

    Comments

    1:00-1:20, Kennedy Union 222

    Description

    Photodynamic therapy is a technique that uses and activates photosensitizing agents through the absorption of light of a certain wavelength in order to produce reactive oxygen species (ROS). When present in a cellular environment, ROS can induce cell damage and oxidative stress leading to cell death. This study introduces a NIR activated BODIPY dye capable of generating both superoxide and singlet oxygen. The synthetic route to this dye along with characterization and evaluation through 1H NMR, electronic absorption spectroscopy, and fluorescence spectroscopy is presented. Using singlet oxygen and superoxide radical quenchers, this dye shows high quantum yields for the production of ROS.

    Publication Date

    4-23-2025

    Project Designation

    Honors Thesis

    Primary Advisor

    Shawn M. Swavey

    Primary Advisor's Department

    Chemistry

    Keywords

    Stander Symposium, College of Arts and Sciences

    Institutional Learning Goals

    Scholarship

    A new BODIPY photosensitizer capable of excitation within the near-infrared (NIR) region of the electromagnetic spectrum

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