Photoreactions of a Water Soluble Poly-Isoquinolpyrrole with Plasmid DNA

Authors

Presenter(s)

Gregory H. Versteeg

Files

Description

Photodynamic Therapy (PDT) is a treatment method for a variety of ailments, including different cancers. It involves light activation of a molecule (photosensitizer) which then reacts with molecular oxygen to destroy tumor cells. Porphyrins are commonly used as photosensitizers due to their light absorption properties and their ability to concentrate in tumor cells but not healthy cells. Unfortunately, porphyrins suffer from poor excitation when irradiated with visible light in the photodynamic therapy window (600-800nm). The photodynamic window is optimal due to the depth of penetration the light reaches and the lack of absorption from naturally occurring compounds in the body. This project involves the synthesis and characterization of a new type of photosensitizer with the goal of creating new molecules that are activated by low energy light.

Publication Date

4-9-2014

Project Designation

Honors Thesis

Primary Advisor

Shawn Swavey

Primary Advisor's Department

Chemistry

Keywords

Stander Symposium project

Disciplines

Arts and Humanities | Business | Education | Engineering | Life Sciences | Medicine and Health Sciences | Physical Sciences and Mathematics | Social and Behavioral Sciences

Recommended Citation

"Photoreactions of a Water Soluble Poly-Isoquinolpyrrole with Plasmid DNA" (2014). Stander Symposium Projects. 488.
https://ecommons.udayton.edu/stander_posters/488