Document Type
Conference Paper
Publication Date
8-24-2025
Publication Source
Proceedings of the 2025 Berry Summer Thesis Institute
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder typically diagnosed at a young age. ASD symptoms include deficits in social behavior, repetitive and restrictive behaviors, anxiety, as well as alterations in sensory gating and sensitivity, learning, memory, and attention performance. Since ASD emerges from a combination of genetic and environmental factors, clinical treatment of these conditions presents with challenges. Being able to model behavioral and neurobiological aspects of this disorder at the preclinical level using rodents allows for further investigation of the pathophysiological basis of this disorder. This mini review will focus on selected genetic and pharmacological rodent models of ASD that have been employed in neuroscience research to understand the neuropathophysiology of this disorder.
Disciplines
Biology | Neuroscience and Neurobiology | Other Neuroscience and Neurobiology
eCommons Citation
Zeller, Rachel, "A Mini Review on Rodent Models of Autism Spectrum Disorder (ASD)" (2025). Proceedings of the Berry Summer Thesis Institute, 2025. 13.
https://ecommons.udayton.edu/uhp_bsti_2025/13
Comments
I would like to thank the Berry Family for their generous donation that made this research possible. I would also like to thank my research mentor Dr. Pothitos M. Pitychoutis for guiding me through this research as well as Ph.D. student Hayden Ott who assisted me on this project. I would like to extend my gratitude to the University of Dayton Biology Department and the University of Dayton’s Honors Program for the opportunity to conduct research. Finally, I would also like to thank the Vivarium staff for maintaining the conditions in the vivarium necessary for our animal research.