Discovering Glioma Inhibitors via Chemical-Genetic Screens in Drosophila Cancer Models

Author(s)

Jordan Terschluse, University of Dayton

Advisor

Madhuri Kango-Singh

Department

Biology

Publication Date

4-26-2020

Document Type

Honors Thesis

Abstract

Today, there are over 250 drugs being used to cure over 100 different types of cancer. We hypothesize that one of the drugs already being used in cancer treatment will either show positive or negative growth when applied specifically to glioblastoma, a type of brain tumor with poor prognosis. Using the fruit fly, Drosophila melanogaster, and 150 tyrosine kinase inhibitors, we can induce tumors and track their growth in response to the drugs. This would open the doors to researching similarities between drugs present in hundreds of chemical libraries. Additionally, the drugs that prove successful through the screenings could start being used in mammalian and clinical trials in the future.

Permission Statement

This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes.

Keywords

Undergraduate research

eCommons Citation

Terschluse, Jordan, "Discovering Glioma Inhibitors via Chemical-Genetic Screens in Drosophila Cancer Models" (2020). Honors Theses. 287.
https://ecommons.udayton.edu/uhp_theses/287