Honors Theses
Advisor
Pothitos Pitychoutis
Department
Biology
Publication Date
4-1-2023
Document Type
Honors Thesis
Abstract
Calcium ions (Ca2+) in the brain play a vital role in prominent neurobiological functions, including neural communication, growth, long-term potentiation, and cell death. Indeed, neuronal Ca2+ homeostasis is carefully maintained, while Ca2+ dysregulation has been linked to various neuropsychiatric disorders including Alzheimer's disease, Parkinson's disease, and Schizophrenia. Herein, we sought to investigate how chronic pharmacological modulation of the sarco-endoplasmic reticulum Ca2+ ATPase (SERCA), an integral endoplasmic reticulum Ca2+-handling effector, may affect spatial learning and memory in the Morris Water Maze test in naïve C57BL/6J mice of both sexes. In the context of the current honors thesis, we gained insights into the relationship between intracellular Ca2+ homeostasis and learning and memory processes. Our efforts are currently targeted towards extending our findings in additional animal models of learning and memory.
Permission Statement
This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes.
Keywords
Undergraduate research
eCommons Citation
Moore, Carter J., "Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice" (2023). Honors Theses. 410.
https://ecommons.udayton.edu/uhp_theses/410
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