Honors Theses
Advisor
Madhuri Kango-Singh, Ph.D.
Department
Biology
Publication Date
4-23-2025
Document Type
Honors Thesis
Abstract
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States, resulting in the deaths of over 50,000 people every year (American Cancer Society, 2023). The similarities shared between mammal and Drosophila melanogaster anatomy within the intestinal tract make Drosophila a great model for studying colorectal cancer. This study will investigate tumor characteristics of a Drosophila CRC model generated by modulating three genes within the key Hippo pathway to create a 3-hit model: p53, RasV12, and APC. The gene combination in the 3-hit model closely emulates how CRC presents in humans and is therefore important to study. This study will characterize the tumors in the guts of Drosophila for invasion, metastasis, and other phenotypes such as blockage of the intestinal tract. The results of this study will expand the discipline’s knowledge of CRC tumor characteristics.
Permission Statement
This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes.
Keywords
Undergraduate research
eCommons Citation
Anderson, Sydney E., "Characterization of a Drosophila CRC 3-hit model using genetic approaches" (2025). Honors Theses. 460.
https://ecommons.udayton.edu/uhp_theses/460
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