Honors Theses
Advisor
Shawn Swavey
Department
Chemistry
Publication Date
Spring 4-2014
Document Type
Honors Thesis
Abstract
With the goal of creating a porphyrin we reacted isoquinol pyrrole, p-fluorobenzaldehyde, and boron trifluoride etherate under appropriate conditions. Instead of a porphyrin being synthesized, we created polyisoquinol pyrrole in high yield and with great absorption properties around 600nm. We characterized this compound via UV/vis spectroscopy, proton NMR, and electrochemistry. The compound was then reacted with [Ru(bipy)2Cl2] to create a cationic compound and this molecule was tested as a possible photosensitizer for photodynamic therapy (PDT) but it was unable to photocleave plasmid DNA above 550nm. The original compound was then methylated and this new compound was also tested as a photosensitizer. This complex was successful at photocleaving DNA above 550nm and appears to be a promising photosensitizer.
Permission Statement
This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes.
Keywords
Undergraduate research
Disciplines
Chemistry | Physical Sciences and Mathematics
eCommons Citation
Versteeg, Gregory, "Photoreactions of a Water Soluble Poly-isoquinolpyrrole with Plasmid DNA" (2014). Honors Theses. 6.
https://ecommons.udayton.edu/uhp_theses/6
