Title

Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

Document Type

Article

Publication Date

2004

Publication Source

Letters in Drug Design & Discovery

Abstract

A computer-generated homology model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.

Inclusive pages

30-34

ISBN/ISSN

1570-1808

Comments

Permission documentation is on file.

Publisher

Bentham Science Publishers

Volume

1

Issue

1

Peer Reviewed

yes