Metabolic and Thermoregulatory Responses to Head Down Suspension of Hypophysectomized Rats

Author(s)

Jon K. Linderman, University of DaytonFollow
Christopher R. Woodman, University of Arizona
Charles M. Tipton, University of Arizona
Juli Evans, University of Arizona
Kristin L. Gosselink, University of Arizona
Richard E. Grindeland, University of Arizona

Document Type

Article

Publication Date

12-1-1993

Publication Source

Journal of Applied Physiology

Abstract

Rats exposed to head-down suspension (HDS) exhibit reductions in maximal O2 consumption (VO2max) and atrophy of select hindlimb muscles. This study tested the hypothesis that an endocrine-deficient rat exposed to HDS would not exhibit reductions in VO2max or hindlimb muscle mass. Hypophysectomized (HYPX) and sham-operated (SHAM) rats were tested for VO2max before and after 28 days of HDS or cage control (CC) conditions. No significant reductions in VO2max were observed in HYPX rats. In contrast, SHAM-HDS rats exhibited a significant reduction in absolute (-16%) and relative (-29%) measures of aerobic capacity. Time course experiments revealed a reduction in VO2max in SHAM-HDS rats within 7 days, suggesting that cardiovascular adjustments to HDS occurred in the 1st wk. HDS was associated with atrophy of the soleus (-42%) in SHAM rats, whereas HYPX rats exhibited atrophy of the soleus (-36%) and plantaris (-13%). SHAM-HDS rats had significantly lower (-38%) soleus citrate synthase activities per gram muscle mass than SHAM-CC, but no significant differences existed between HYPX-HDS and -CC rats. HDS rats had an impaired ability to thermoregulate, as indicated by significantly greater temperature increases per unit run time, compared with their CC counterparts. Pretreatment plasma epinephrine levels were significantly lower in HYPX than in SHAM rats. Norepinephrine concentration was similar for all groups except HYPX-HDS, in which it was significantly higher. HDS had no significant effect on thyroxine or triiodothyronine. SHAM-HDS rats had significantly lower concentrations of testosterone and growth hormone.

Inclusive pages

2718-2726

ISBN/ISSN

8750-7587

Comments

Permission documentation on file.

Copyright

Copyright © 1993, American Physiological Society

Publisher

American Physiological Society

Volume

75

Issue

6

Peer Reviewed

yes

eCommons Citation

Linderman, Jon K.; Woodman, Christopher R.; Tipton, Charles M.; Evans, Juli; Gosselink, Kristin L.; and Grindeland, Richard E., "Metabolic and Thermoregulatory Responses to Head Down Suspension of Hypophysectomized Rats" (1993). Health and Sport Science Faculty Publications. 96.
https://ecommons.udayton.edu/hss_fac_pub/96