Molecular Mechanisms of Muscle Disuse Atrophy (and Strategies of Prevention)

Author(s)

Jon K. Linderman, University of DaytonFollow
Christopher R. Kirby, University of Texas
Frank W. Booth, University of Texas

Document Type

Article

Publication Date

1992

Publication Source

Integration of Medical and Sports Sciences

Abstract

Atrophy of skeletal muscle diminishes the quality of life of a human or animal by reducing their freedom of movement. Unfortunately, muscle atrophy occurs all too commonly. Atrophy of skeletal muscle often is initiated, or enhanced, by decreased physical activity associated with senescence, postoperative repair from orthopedic surgeries, spinal cord injury, cancer cachexia, or chronic bed rest resulting from disease. Although a clinical condition, itself, may produce some atrophy of skeletal muscle, the common factor among the above afflictions is that they reduce muscle usage. To develop a scientifically rational method for preventing muscle atrophy it will be necessary to understand the mechanism(s) by which reduced load bearing triggers the loss of muscle mass.

Inclusive pages

142-149

ISBN/ISSN

9783805555791

Comments

Permission documentation on file.

Copyright

Copyright © 1992, Karger Press

Publisher

Karger Press

Volume

37

eCommons Citation

Linderman, Jon K.; Kirby, Christopher R.; and Booth, Frank W., "Molecular Mechanisms of Muscle Disuse Atrophy (and Strategies of Prevention)" (1992). Health and Sport Science Faculty Publications. 98.
https://ecommons.udayton.edu/hss_fac_pub/98